Document Detail

"Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?
MedLine Citation:
PMID:  18508624     Owner:  NLM     Status:  MEDLINE    
It is unclear what role vision plays in guiding mouse behaviour, since the mouse eye is of comparably low optical quality, and mice are considered to rely primarily on other senses. All C3H substrains are homozygous for the Pde6b(rd1) mutation and get blind by weaning age. To study the impact of the Pde6b(rd1) mutation on mouse behaviour and physiology, sighted C3H (C3H.Pde6b+) and normal C3H/HeH mice were phenotyped for different aspects. We confirmed retinal degeneration 1 in C3H/HeH mice, and the presence of a morphologically normal retina as well as visual ability in C3H.Pde6b+ mice. However, C3H.Pde6b+ mice showed an abnormal retinal function in the electroretinogram response, indicating that their vision was not normal as expected. C3H.Pde6b+ mice showed reduced latencies for several behaviours without any further alterations in these behaviours in comparison to C3H/HeH mice, suggesting that visual ability, although impaired, enables earlier usage of the behavioural repertoire in a novel environment, but does not lead to increased activity levels. These results emphasize the importance of comprehensive behavioural and physiological phenotyping.
Sabine M Hoelter; Claudia Dalke; Magdalena Kallnik; Lore Becker; Marion Horsch; Anja Schrewe; Jack Favor; Thomas Klopstock; Johannes Beckers; Boris Ivandic; Valérie Gailus-Durner; Helmut Fuchs; Martin Hrabé de Angelis; Jochen Graw; Wolfgang Wurst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  13     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-29     Completed Date:  2008-09-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5810-23     Citation Subset:  IM    
Institute of Developmental Genetics, Helmholtz Center Munich-German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany.
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MeSH Terms
Behavior, Animal*
Blood Pressure
Cardiovascular Physiological Phenomena
Exploratory Behavior
Fluorescein Angiography
Gene Expression Profiling
Lactates / metabolism
Mice, Inbred C3H
Motor Activity
Nystagmus, Optokinetic / physiology
Vision Tests
Vision, Ocular / physiology*
Reg. No./Substance:

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