| Of mice and men: The benefits of caloric restriction, exercise, and mimetics. | |
| | |
MedLine Citation:
|
PMID: 22210414 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
During aging there is an increasing imbalance of energy intake and expenditure resulting in obesity, frailty, and metabolic disorders. For decades, research has shown that caloric restriction (CR) and exercise can postpone detrimental aspects of aging. These two interventions invoke a similar physiological signature involving pathways associated with stress responses and mitochondrial homeostasis. Nonetheless, CR is able to delay aging processes that result in an increase of both mean and maximum lifespan, whereas exercise primarily increases healthspan. Due to the strict dietary regime necessary to achieve the beneficial effects of CR, most studies to date have focused on rodents and non-human primates. As a consequence, there is vast interest in the development of compounds such as resveratrol, metformin and rapamycin that would activate the same metabolic- and stress-response pathways induced by these interventions without actually restricting caloric intake. Therefore the scope of this review is to (i) describe the benefits of CR and exercise in healthy individuals, (ii) discuss the role of these interventions in the diseased state, and (iii) examine some of the promising pharmacological alternatives such as CR- and exercise-mimetics. |
| | |
Authors:
|
Evi M Mercken; Bethany A Carboneau; Susan M Krzysik-Walker; Rafael de Cabo |
Related Documents
:
|
21801244 - Two-minute heart rate recovery after cycle ergometer exercise and all-cause mortality i... 22160404 - Exercise-induced right ventricular dysfunction and structural remodelling in endurance ... 19952824 - Estimation of resistance exercise energy expenditure using accelerometry. 7451284 - Energy expended during oxygen deficit period of submaximal exercise in man. 9385914 - Effects of chronic hypoxemia on chemosensitivity in patients with univentricular heart. 7194794 - Changes in 2,3-diphosphoglycerate (2,3-dpg) after exercise. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-20 |
Journal Detail:
|
Title: Ageing research reviews Volume: - ISSN: 1872-9649 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2012-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101128963 Medline TA: Ageing Res Rev Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Published by Elsevier B.V. |
Affiliation:
|
Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gastrointestinal Endoscopy and Mucosal Biopsy in the First Year of Life: Indications and Outcome.
Next Document: Indication of liver transplantation for jaundice-free biliary atresia with portal hypertension.