Document Detail


Of mice and men: the benefits of caloric restriction, exercise, and mimetics.
MedLine Citation:
PMID:  22210414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During aging there is an increasing imbalance of energy intake and expenditure resulting in obesity, frailty, and metabolic disorders. For decades, research has shown that caloric restriction (CR) and exercise can postpone detrimental aspects of aging. These two interventions invoke a similar physiological signature involving pathways associated with stress responses and mitochondrial homeostasis. Nonetheless, CR is able to delay aging processes that result in an increase of both mean and maximum lifespan, whereas exercise primarily increases healthspan. Due to the strict dietary regime necessary to achieve the beneficial effects of CR, most studies to date have focused on rodents and non-human primates. As a consequence, there is vast interest in the development of compounds such as resveratrol, metformin and rapamycin that would activate the same metabolic- and stress-response pathways induced by these interventions without actually restricting caloric intake. Therefore the scope of this review is to (i) describe the benefits of CR and exercise in healthy individuals, (ii) discuss the role of these interventions in the diseased state, and (iii) examine some of the promising pharmacological alternatives such as CR- and exercise-mimetics.
Authors:
Evi M Mercken; Bethany A Carboneau; Susan M Krzysik-Walker; Rafael de Cabo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review     Date:  2011-12-20
Journal Detail:
Title:  Ageing research reviews     Volume:  11     ISSN:  1872-9649     ISO Abbreviation:  Ageing Res. Rev.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-05-18     Completed Date:  2013-02-26     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101128963     Medline TA:  Ageing Res Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  390-8     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
Affiliation:
Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Biomimetic Materials / metabolism*,  therapeutic use
Caloric Restriction* / methods
Energy Intake / physiology
Exercise / physiology*
Humans
Longevity / physiology
Metabolic Diseases / drug therapy,  metabolism,  prevention & control
Mice
Grant Support
ID/Acronym/Agency:
ZIA AG000363-03/AG/NIA NIH HHS; ZIA AG000368-07/AG/NIA NIH HHS
Comments/Corrections

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