| C57BL/6J, DBA/2J, and DBA/2J.Gpnmb mice have different visual signal processing in the inner retina. | |
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MedLine Citation:
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PMID: 21203347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To characterize differences in retinal ganglion cell (RGC) function in mouse strains relevant to disease models. C57BL/6J (B6) and DBA/2J (D2) are the two most common mouse strains; D2 has two mutated genes, tyrosinase-related protein 1 (Tyrp1) and glycoprotein non-metastatic melanoma protein B (Gpnmb), causing iris disease and intraocular pressure (IOP) elevation after 6 months of age that results in RGC degeneration, and is the most widely used model of glaucoma. DBA/2J.Gpnmb(+) (D2.Gpnmb(+)) is the wild type for the Gpnmb mutation and does not develop IOP elevation and glaucoma. METHODS: Young (2-4 months of age) B6, D2, and D2.Gpnmb(+) mice (n=6 for each group) were tested with pattern electroretinogram (PERG) in response to different contrasts and spatial frequencies. PERG amplitude and latency dependencies on stimulus parameters (transfer functions) were established for each mouse strain, together with corresponding thresholds for contrast and spatial resolution. RESULTS: PERG analysis showed that B6, D2, and D2.Gpnmb(+) mice had comparable contrast threshold and spatial resolution. Suprathreshold spatial contrast processing, however, had different characteristics in the three strains. PERG amplitude and latency changes with increasing contrast were different between B6 and D2 as well as between D2 and D2.Gpnmb(+). CONCLUSIONS: B6, D2, and D2.Gpnmb(+) mice have different characteristics of PERG spatial contrast processing consistent with different mechanisms of contrast gain control. This may imply differences in the activity of underlying PERG generators and synaptic circuitry in the inner retina. |
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Authors:
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Vittorio Porciatti; Tsung-Han Chou; William J Feuer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-12-31 |
Journal Detail:
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Title: Molecular vision Volume: 16 ISSN: 1090-0535 ISO Abbreviation: Mol. Vis. Publication Date: 2010 |
Date Detail:
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Created Date: 2011-01-04 Completed Date: 2011-02-08 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 9605351 Medline TA: Mol Vis Country: United States |
Other Details:
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Languages: eng Pagination: 2939-47 Citation Subset: IM |
Affiliation:
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Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA. vporciatti@med.miami.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Sensitivity / physiology Electroretinography Eye Proteins / metabolism* Membrane Glycoproteins / metabolism* Mice Mice, Inbred C57BL Mice, Inbred DBA Reaction Time / physiology Retina / physiology* Vision, Ocular / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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P30EY014801/EY/NEI NIH HHS; R01EY019077/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Eye Proteins; 0/Gpnmb protein, mouse; 0/Membrane Glycoproteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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