| Of mice and Myc: c-Myc and mammary tumorigenesis. | |
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MedLine Citation:
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PMID: 15082916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The proto-oncogene c- myc is involved in regulating proliferation and apoptosis, and its deregulation via genomic and postgenomic mechanisms, contributes to the development and progression of multiple human cancers, including those of the breast. Deregulated expression of c-Myc also contributes to neoplastic transformation by altering cellular differentiation pathways and by facilitating mutagenesis through induction of genomic instability. Transgenic and gene-knockout mice are frequently utilized to resolve the mechanisms through which specific genes influence the development and progression of malignancies. In this review, we discuss how research findings obtained from various c- myc transgenic mammary tumor models help to improve our resolution of c-Myc's role both in tumorigenesis of the murine mammary gland and cancer of the human breast. |
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Authors:
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M Hunter Jamerson; Michael D Johnson; Robert B Dickson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of mammary gland biology and neoplasia Volume: 9 ISSN: 1083-3021 ISO Abbreviation: J Mammary Gland Biol Neoplasia Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-04-14 Completed Date: 2004-12-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9601804 Medline TA: J Mammary Gland Biol Neoplasia Country: United States |
Other Details:
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Languages: eng Pagination: 27-37 Citation Subset: IM |
Affiliation:
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Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Breast Neoplasms / genetics*, physiopathology* Cell Differentiation Cell Transformation, Neoplastic* Disease Models, Animal Female Gene Expression Regulation, Neoplastic Genes, myc* Humans Mammary Glands, Animal / cytology, pathology* Mammary Neoplasms, Animal / genetics*, physiopathology* Mice Mice, Knockout Proto-Oncogene Proteins c-myc / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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1R01AG1496/AG/NIA NIH HHS; 1R01CA72460/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Myc protein, mouse; 0/Proto-Oncogene Proteins c-myc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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