Document Detail


The miRNAs in the pathgenesis of osteosarcoma.
MedLine Citation:
PMID:  23276964     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. MicroRNAs (miRNAs) are non-coding small RNAs, usually 18-25 nucleotides in length, which repress translation and cleave mRNA by base-pairing to the 3 untranslated region of the target genes. miRNAs have demonstrated far-reaching effects on the cellular biology of development and cancer. Their role in osteosarcomagenesis remains largely unexplored. A number of reports have investigated the role of microRNAs in osteosarcoma. This review summeizes the recent research progress of miRNA in the osteosarcome.
Authors:
Wenqing Liang; Bo Gao; Peng Fu; Shuogui Xu; Yu Qian; Qingge Fu
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  788-94     Citation Subset:  IM    
Affiliation:
Department of Orthopedics, Changhai Hospital of Second Military Medical University, Shanghai 200433, China.
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MeSH Terms
Descriptor/Qualifier:
Bone Neoplasms / genetics*
Cell Proliferation
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor / physiology
Humans
MicroRNAs / genetics*,  therapeutic use
Neoplasm Invasiveness / genetics
Oncogenes / physiology
Osteosarcoma / genetics*
Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors
Tumor Suppressor Protein p53 / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/MicroRNAs; 0/Mirn140 microRNA, human; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tumor Suppressor Protein p53

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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