Document Detail


miRNAs as biomarkers for management of patients with colorectal cancer.
MedLine Citation:
PMID:  20945991     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
miRNAs serve as micromanagers, negatively regulating gene expression. Since altered miRNA expression is implicated in the pathobiology of various cancers, including colorectal cancers (CRCs), these molecules serve as potential therapeutic targets. Manipulation of miRNAs may offer an alternative therapy for chemo- and radio-resistant CRCs. For CRC patients, miRNA expression patterns can be used for diagnosis, and to predict prognosis and efficacy of therapy. This article describes the methodological approaches for miRNA measurement, their function in the pathobiology of CRCs and their potential clinical utility.
Authors:
Upender Manne; Chandrakumar Shanmugam; Liselle Bovell; Venkat R Katkoori; Harvey L Bumpers
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Biomarkers in medicine     Volume:  4     ISSN:  1752-0371     ISO Abbreviation:  Biomark Med     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-15     Completed Date:  2011-02-04     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101312535     Medline TA:  Biomark Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  761-70     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294-7331, USA. manne@uab.edu
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MeSH Terms
Descriptor/Qualifier:
Chromosomal Instability
Colorectal Neoplasms / diagnosis*,  genetics,  therapy*
Early Detection of Cancer
Epigenesis, Genetic
Humans
MicroRNAs / analysis,  metabolism*
Microsatellite Instability
Prognosis
Tumor Markers, Biological / genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
2U54-CA118948/CA/NCI NIH HHS; 3R01-CA098932/CA/NCI NIH HHS; R01 CA098932/CA/NCI NIH HHS; R01 CA098932-05S1/CA/NCI NIH HHS; R03 CA139629/CA/NCI NIH HHS; R03 CA139629-02/CA/NCI NIH HHS; R03-CA139629/CA/NCI NIH HHS; U54 CA118948/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/MicroRNAs; 0/Tumor Markers, Biological
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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