Document Detail


miRNAs as therapeutic targets in ischemic heart disease.
MedLine Citation:
PMID:  20560049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ischemic heart disease is a form of congestive heart failure that is caused by insufficient blood supply to the heart, resulting in a loss of viable tissue. In response to the injury, the non-ischemic myocardium displays signs of secondary remodeling, like interstitial fibrosis and hypertrophy of cardiac myocytes. This remodeling process further deteriorates pump function and increases susceptibility to arrhythmias. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression in a sequence-dependent manner. Recently, several groups identified miRNAs as crucial gene regulators in response to myocardial infarction (MI) and during post-MI remodeling. In this review, we discuss how modulation of these miRNAs represents a promising new therapeutic strategy to improve the clinical outcome in ischemic heart disease.
Authors:
Robert J A Frost; Eva van Rooij
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-03-30
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  3     ISSN:  1937-5395     ISO Abbreviation:  J Cardiovasc Transl Res     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-18     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  280-9     Citation Subset:  IM    
Affiliation:
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390-9148, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Fibrosis
Gene Expression Regulation
Gene Therapy*
Humans
MicroRNAs / metabolism*
Myocardial Ischemia / genetics,  pathology,  physiopathology,  therapy*
Myocardium / metabolism*,  pathology
Treatment Outcome
Ventricular Remodeling / genetics
Chemical
Reg. No./Substance:
0/MicroRNAs

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