Document Detail


miRNA and neurons.
MedLine Citation:
PMID:  19863258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Micro RNAs (miRNAs) are endogenous noncoding RNAs that are important for gene regulation. This review provides an overview of miRNA biogenesis and mechanism of action. The review focuses on studies relating to the spatial and temporal regulation of gene expression in neurons. Studies have shown that while some miRNA are expressed during neuronal differentiation, others are expressed only in mature neurons or synapses. This review includes reports that associate miRNA dysfunction with neurodegenerative disorders. Finally, the review raises points that may be helpful for researchers in exploring areas that have remained unanswered vis-??-vis the biogenesis and regulatory roles of miRNAs.
Authors:
S Trivedi; G Ramakrishna
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  119     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-29     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1995-2016     Citation Subset:  IM    
Affiliation:
Computational Biology Lab, Department of Zoology, JN Vyas University, Jodhpur, Rajasthan, India. svtrived@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / growth & development,  metabolism*
Brain Chemistry / genetics*
Cell Differentiation / genetics
Gene Expression Regulation / genetics*
Heredodegenerative Disorders, Nervous System / genetics,  metabolism,  physiopathology
Humans
MicroRNAs / genetics,  metabolism*
Neurogenesis / genetics
Neurons / metabolism*
RNA, Messenger / genetics,  metabolism
Chemical
Reg. No./Substance:
0/MicroRNAs; 0/RNA, Messenger

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