Document Detail


miRNA-155 upregulation and complement factor H deficits in Down's syndrome.
MedLine Citation:
PMID:  22182977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Down's syndrome, a congenital disorder associated with cognitive impairment and early-onset Alzheimer's disease, is a progressive genetic pathology resulting from full or partial triplication of chromosome 21. Down's syndrome brain is typified by activated microglia, increases in inflammatory signaling, and an aberrant immune system. In these studies, a screening of micro-RNA (miRNA) from Down's syndrome brain and peripheral tissues indicated an upregulation of a chromosome 21-encoded miRNA-155 and a decrease in the abundance of the miRNA-155 mRNA target complement factor H (CFH), an important repressor of the innate immune response. Stressed primary human neuronal-glial cells indicated both miRNA-155 increase and CFH downregulation, an effect that was reversed using anti-miRNA-155. These findings suggest that immunopathological deficits associated with Down's syndrome can, in part, be explained by a generalized miRNA-155-mediated downregulation of CFH that may contribute to both brain and systemic immune pathology.
Authors:
Yuan Y Li; Peter N Alexandrov; Aileen I Pogue; Yuhai Zhao; Surjyadipta Bhattacharjee; Walter J Lukiw
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  23     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  2012-05-10     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  168-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / metabolism
Complement Factor H / genetics*,  metabolism
Down Syndrome / genetics*,  metabolism
Down-Regulation
Female
Humans
MicroRNAs / metabolism*
Middle Aged
Neuroglia / metabolism
Neurons / metabolism
Up-Regulation
Grant Support
ID/Acronym/Agency:
AG038834/AG/NIA NIH HHS; AG18031/AG/NIA NIH HHS; P50 AG16573/AG/NIA NIH HHS; R01 AG018031/AG/NIA NIH HHS; R01 AG018031-05S1/AG/NIA NIH HHS; R01 AG038834/AG/NIA NIH HHS; R01 AG038834-02/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/MicroRNAs; 80295-65-4/Complement Factor H
Comments/Corrections

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