| miRNA-146a in rheumatoid arthritis: a new therapeutic strategy. | |
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MedLine Citation:
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PMID: 21751952 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Evaluation of: Nakasa T, Shibuya H, Nagata Y, Niimoto T, Ochi M: The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis. Arthritis Rheum. 63(6), 1582-1590 (2011). miRNA-146a (miR-146a) has been shown to play an important role in the negative regulation of inflammatory innate immune responses, and is differentially expressed in a number of human diseases including rheumatoid arthritis. However, evidence for the potential therapeutic use of miR-146a in human disease has been lacking. The current paper demonstrates the potential therapeutic application of miR-146a for rheumatoid arthritis by demonstrating the inhibitory effect of miR-146a on osteoclastogenesis in vitro. Moreover, using a collagen-induced arthritis mouse model, they were able to demonstrate that intravenous administration of double-stranded miR-146a resulted in the suppression of cartilage and bone destruction, despite relatively unaffected immune cell infiltration of the synovium and inflammatory cytokine expression. |
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Authors:
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Kaleb M Pauley; Seunghee Cha |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunotherapy Volume: 3 ISSN: 1750-7448 ISO Abbreviation: Immunotherapy Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485158 Medline TA: Immunotherapy Country: England |
Other Details:
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Languages: eng Pagination: 829-31 Citation Subset: IM |
Affiliation:
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University of Florida College of Dentistry, Department of Oral & Maxillofacial Diagnostic Sciences, 1600 SW Archer Rd, Gainesville, FL 32610, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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