Document Detail


miR-29b moulds the tumour microenvironment to repress metastasis.
MedLine Citation:
PMID:  23377028     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Tumour cells are influenced by their microenvironment, which can promote uncontrolled growth, invasion and metastasis. The GATA3 transcription factor is now shown to regulate the tumour microenvironment by inducing the expression of miR-29b in cancer cells. This microRNA in turn inhibits the expression of genes involved in angiogenesis and extracellular matrix signalling and remodelling to suppress metastasis.
Authors:
Sonia A Melo; Raghu Kalluri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature cell biology     Volume:  15     ISSN:  1476-4679     ISO Abbreviation:  Nat. Cell Biol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-02-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890575     Medline TA:  Nat Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  139-40     Citation Subset:  IM    
Affiliation:
Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston 77054, Texas, USA.
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