Document Detail


miR-210: More than a silent player in hypoxia.
MedLine Citation:
PMID:  21360638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple studies have consistently established that miR (microRNA)-210 induction is a feature of the hypoxic response in both normal and transformed cells. Here, we discuss the emerging biochemical functions of this miRNA and anticipate potential clinical applications. miR-210 is a robust target of hypoxia-inducible factor, and its overexpression has been detected in a variety of cardiovascular diseases and solid tumors. High levels of miR-210 have been linked to an in vivo hypoxic signature and associated with adverse prognosis in cancer patients. A wide spectrum of miR-210 targets have been identified, with roles in mitochondrial metabolism, angiogenesis, DNA repair, and cell survival. Such targets may broadly affect the evolution of tumors and other pathological settings, such as ischemic disorders. Harnessing the knowledge of miR-210's actions may lead to novel diagnostic and therapeutic approaches.
Authors:
Cecilia Devlin; Simona Greco; Fabio Martelli; Mircea Ivan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-02-24
Journal Detail:
Title:  IUBMB life     Volume:  63     ISSN:  1521-6551     ISO Abbreviation:  IUBMB Life     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-01     Completed Date:  2011-06-24     Revised Date:  2014-10-12    
Medline Journal Info:
Nlm Unique ID:  100888706     Medline TA:  IUBMB Life     Country:  England    
Other Details:
Languages:  eng     Pagination:  94-100     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / genetics,  metabolism*
Apoptosis
Biological Markers / analysis*
Cardiovascular Diseases / genetics,  metabolism
Cell Hypoxia / genetics
Cell Line, Tumor
Cell Survival
DNA Repair
Gene Expression Profiling
Gene Expression Regulation
Humans
Hypoxia-Inducible Factor 1 / genetics,  metabolism*
Mice
Mice, Inbred Strains
MicroRNAs* / biosynthesis,  genetics
Mitochondria / metabolism
Molecular Targeted Therapy
Neoplasms / genetics,  metabolism
Neovascularization, Pathologic / genetics,  metabolism
Oxidative Stress
Prognosis
Grant Support
ID/Acronym/Agency:
R01 CA155332/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Hypoxia-Inducible Factor 1; 0/MicroRNAs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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