Document Detail

miR-21, miR-221 and miR-222 expression and prostate cancer recurrence among obese and non-obese cases.
MedLine Citation:
PMID:  23353719     Owner:  NLM     Status:  Publisher    
Recent evidence shows that certain microRNAs (miRNAs) play a role in both obesity and prostate cancer recurrence, but the association between the expression of these miRNAs and obesity in prostate cancer recurrence is unknown. In this study, we examined the effect of the interaction between obesity and miR-21, miR-221 or miR-222 expression on prostate cancer recurrence among 28 recurrent and 37 non-recurrent prostate cancer cases. miRNA expression was determined using quantitative real-time polymerase chain reaction. Cox proportional hazard models adjusting for age at diagnosis, clinical stage and Gleason score were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for recurrence free survival. A significantly (P=0.014) higher proportion of recurrent cases (78.6%) than non-recurrent cases (48.6%) had a low expression of miR-21 and the difference was more prominent in obese than non-obese patients. Multivariate analysis showed that the expression of miR-21 was an independent risk factor for recurrence in obese (HR=6.15, 95% CI=1.04-36.48, P=0.045), but not in non-obese (HR=1.28, 95% CI=0.30-5.49, P=0.74) cases. A significant association with recurrence was not observed for the expression of miR-221 and miR-222. In summary, our findings show that miR-21 is associated with prostate cancer recurrence after radical prostatectomy and suggest that the differential expression of miR-21 is more prominent in obese than in non-obese cases. Future larger studies are warranted to confirm these initial findings and to elucidate the mechanisms involved.Asian Journal of Andrology advance online publication, 28 January 2013; doi:10.1038/aja.2012.160.
Ernest K Amankwah; Evelyn Anegbe; Hyun Park; Julio Pow-Sang; Ardeshir Hakam; Jong Y Park
Related Documents :
23251519 - Adeno-associated virus vector mediated expression of an oncogenic retroviral envelope p...
7342769 - Mortality studies of smelter workers.
7697139 - Occupational exposure to hydrazine and subsequent risk of cancer.
23532689 - Clinicopathological significance of btf3 expression in colorectal cancer.
8326349 - Pattern of mortality among danish thorotrast patients.
18609549 - A cohort mortality study of chemical laboratory workers at department of energy nuclear...
21280589 - Dinoxin b, a withanolide from datura inoxia leaves with specific cytotoxic activities.
19337569 - Models of ovarian cancer metastasis: murine models.
24456439 - Trends of vulvar cancer.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  Asian journal of andrology     Volume:  -     ISSN:  1745-7262     ISO Abbreviation:  Asian J. Androl.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100942132     Medline TA:  Asian J Androl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Serum prostate-specific antigen as a predictor of prostate volume and lower urinary tract symptoms i...
Next Document:  Tamsulosin alters levofloxacin pharmacokinetics in prostates derived from rats with acute bacterial ...