| miR-15a and 16-1 are downregulated in CD4(+) T cells of multiple sclerosis relapsing patients. | |
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MedLine Citation:
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PMID: 22463747 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract The pathology of relapsing-remitting multiple sclerosis (RR-MS) is largely attributed to activated autoreactive effector T lymphocytes. The influence of microRNAs on the immune response has been shown to occur in different pathways of lymphocyte differentiation and function. Here the expression of the miRNAs miR-15a/16-1 in PBMC, CD4(+) and CD8(+) from RR-MS patients has been investigated. BCL2, a known miR-15a/16-1 target, has also been analyzed. The results have shown that miR-15a/16-1 is downregulated in CD4(+) T cells, whereas BCL2 is highly expressed in RR-MS patients only. Our data suggest that miR-15a/16-1 can also modulate the BCL2 gene expression in CD4(+) T cells from RR-MS patients, thereby affecting apoptosis processes. |
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Authors:
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Julio C C Lorenzi; Doralina G Brum; Dalila L Zanette; Alessandra de Paula Alves Souza; Fernanda Gonçalves Barbuzano; Antonio Carlos Dos Santos; Amilton Antunes Barreira; Wilson Araujo Silva |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-2 |
Journal Detail:
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Title: The International journal of neuroscience Volume: - ISSN: 1563-5279 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0270707 Medline TA: Int J Neurosci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1São Paulo University Medical school of Ribeirão Preto, Genetics Department, Ribeirão Preto, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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