Document Detail


miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells.
MedLine Citation:
PMID:  23010597     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Recent studies have implied that miRNAs act as crucial modulators for Epithelial-to-mesenchymal transition (EMT). We found that miR-134 expression correlated with invasive potential and EMT phenotype of NSCLC cells. Functional assays demonstrated that miR-134 inhibited EMT in NSCLC cells. In addition, we showed that Forkhead Box M1 (FOXM1) is a direct target of miR-134. Knockdown of FOXM1 reversed EMT resembling that of miR-134 overexpression. We further found that FOXM1 was involved in TGF-β1-induced EMT in A549 cells. These findings suggest that miR-134 acts as a novel EMT suppressor in NSCLC cells.
Authors:
Jipeng Li; Yiping Wang; Jianping Luo; Zhongming Fu; Jianfei Ying; Yanhong Yu; Wanjun Yu
Related Documents :
25112287 - Alpha-lipoic acid enhances dmso-induced cardiomyogenic differentiation of p19 cells.
23128297 - Identification of glycosyltransferases involved in cell wall synthesis of wheat endosperm.
23955587 - Oral administration of an hsp90 inhibitor, 17-dmag, intervenes tumor-cell infiltration ...
23936187 - Conserved roles of the prion protein domains on subcellular localization and cell-cell ...
1655287 - Estrogen delays entry of the yeast saccharomyces cerevisiae into meiosis.
7706287 - A mutation in the schizosaccharomyces pombe rae1 gene causes defects in poly(a)+ rna ex...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-22
Journal Detail:
Title:  FEBS letters     Volume:  -     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Department of Clinical Laboratory, Yinzhou People's Hospital, Ningbo 315040, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Site-specific cleavage of mutant ABL mRNA by DNAzyme is facilitated by peptide nucleic acid binding ...
Next Document:  Homodimeric pregnancy-associated plasma protein-A in normal human placenta of first and third trimes...