| The methoxychlor metabolite, HPTE, inhibits rat luteal cell progesterone production. | |
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MedLine Citation:
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PMID: 21664964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RESULTS: Exposure to 100 nM HPTE reduced progesterone production by luteal cells with progressive declines to <22% of control at 500 nM HPTE. Similarly, HPTE progressively inhibited progesterone formation and P450scc catalytic activity of hCG- or 8 Br-cAMP-stimulated luteal cells. However, HPTE did not alter mRNA and protein levels of P450scc. Compounds acting as estrogen (17 β-estradiol, bisphenol-A or octylphenol), antiestrogen (ICI) or antiandrogen (monobutyl phthalate, flutamide or M-2) added alone to luteal cells did not mimic the action of HPTE on progesterone and P450scc activity. These results suggest that HPTE directly inhibits P450scc catalytic activity resulting in reduced progesterone formation, and this action was not mediated through estrogen or androgen receptors. |
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Authors:
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Yucel Akgul; Raymond C Derk; Terence Meighan; K Murali Krishna Rao; Eisuke P Murono |
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Publication Detail:
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Type: Journal Article Date: 2011-06-02 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 32 ISSN: 1873-1708 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-22 Completed Date: 2011-11-15 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 77-84 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Inc. |
Affiliation:
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Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA. akgulyucel@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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8-Bromo Cyclic Adenosine Monophosphate
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pharmacology Animals Cholesterol Side-Chain Cleavage Enzyme / metabolism Chorionic Gonadotropin / pharmacology Estrogens / pharmacology Female Gene Expression / drug effects Luteal Cells / drug effects*, metabolism Phenols / toxicity* Progesterone / antagonists & inhibitors, metabolism* RNA, Messenger / metabolism Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Estrogens; 0/Phenols; 0/RNA, Messenger; 23583-48-4/8-Bromo Cyclic Adenosine Monophosphate; 57-83-0/Progesterone; EC 1.14.15.6/Cholesterol Side-Chain Cleavage Enzyme; H58165YO91/2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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