Document Detail

The methoxychlor metabolite, HPTE, inhibits rat luteal cell progesterone production.
MedLine Citation:
PMID:  21664964     Owner:  NLM     Status:  MEDLINE    
RESULTS: Exposure to 100 nM HPTE reduced progesterone production by luteal cells with progressive declines to <22% of control at 500 nM HPTE. Similarly, HPTE progressively inhibited progesterone formation and P450scc catalytic activity of hCG- or 8 Br-cAMP-stimulated luteal cells. However, HPTE did not alter mRNA and protein levels of P450scc. Compounds acting as estrogen (17 β-estradiol, bisphenol-A or octylphenol), antiestrogen (ICI) or antiandrogen (monobutyl phthalate, flutamide or M-2) added alone to luteal cells did not mimic the action of HPTE on progesterone and P450scc activity. These results suggest that HPTE directly inhibits P450scc catalytic activity resulting in reduced progesterone formation, and this action was not mediated through estrogen or androgen receptors.
Yucel Akgul; Raymond C Derk; Terence Meighan; K Murali Krishna Rao; Eisuke P Murono
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Publication Detail:
Type:  Journal Article     Date:  2011-06-02
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  32     ISSN:  1873-1708     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-22     Completed Date:  2011-11-15     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-84     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA.
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MeSH Terms
8-Bromo Cyclic Adenosine Monophosphate / pharmacology
Cholesterol Side-Chain Cleavage Enzyme / metabolism
Chorionic Gonadotropin / pharmacology
Estrogens / pharmacology
Gene Expression / drug effects
Luteal Cells / drug effects*,  metabolism
Phenols / toxicity*
Progesterone / antagonists & inhibitors,  metabolism*
RNA, Messenger / metabolism
Rats, Sprague-Dawley
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Estrogens; 0/Phenols; 0/RNA, Messenger; 23583-48-4/8-Bromo Cyclic Adenosine Monophosphate; 57-83-0/Progesterone; EC Side-Chain Cleavage Enzyme; H58165YO91/2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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