Document Detail

A method for studying epithelial-mesenchymal interactions in human oral mucosal lesions.
MedLine Citation:
PMID:  293885     Owner:  NLM     Status:  MEDLINE    
A system has been developed for examining connective tissue influence on keratinization of normal and leukoplakic human oral epithelia. Paired biopsy specimens of normal and leukoplakic mucosa were left intact or were incubated in 1 mM EDTA to permit epithelial-connective tissue separation and various recombinations of the epithelium and connective tissue. The tissues were transplanting to subdermal sites of "nude" (nu/nu) mice and were protected by polyethylene capsules. 44% of implants performed were recovered apparently vital. Preexisting structure was retained after epithelial-connective tissue separation and self-recombination. Cross-recombined specimens showed changes in patterns of keratinization including changes of keratinized leukoplakic epithelium to a non-keratinized type.
I C Mackenzie; E Dabelsteen; B Roed-Petersen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of dental research     Volume:  87     ISSN:  0029-845X     ISO Abbreviation:  Scand J Dent Res     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1980-03-17     Completed Date:  1980-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0270023     Medline TA:  Scand J Dent Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  234-43     Citation Subset:  D; IM    
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MeSH Terms
Cell Differentiation
Connective Tissue / pathology,  physiology,  transplantation
Epithelium / pathology,  physiology,  transplantation
Keratins / analysis
Leukoplakia, Oral / etiology,  pathology*
Mice, Nude
Mouth Mucosa / pathology*,  transplantation
Transplantation, Heterologous
Reg. No./Substance:

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