| A method of stimulating different segments of the autonomic outflow from the spinal column to various organs in the pithed cat and rat. | |
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MedLine Citation:
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PMID: 5275866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. A simple method of stimulating different segments of the autonomic outflow from the spinal column in the pithed cat and rat is described.2. Using a movable Teflon-shielded electrode inserted into the vertebral canal and an indifferent electrode under the skin, reproducible responses were obtained from the adrenals, the bladder, the blood vessels, the colon, the heart and the vas deferens. The level and number of segments stimulated was altered by varying the depth of insertion of the Teflon tube and the length of central steel electrode protruding from it.3. The degree of localization of the stimulus seemed satisfactory since it was possible by stimulating the sacral parasympathetic outflow to the bladder and colon or the lumbar sympathetic outflow to the vas deferens, to elicit responses from these organs with little effect on the cardiovascular system. Stimulation at higher levels of the thoracic sympathetic outflow permitted discrimination between the pressor and cardio-accelerator responses.4. Hexamethonium (1 mg/kg) inhibited all the responses, but the colonic response, which occurred only after a latent period, was especially sensitive to ganglion blockade. Atropine (1 mg/kg) inhibited the bladder response by 50% but only prolonged the latency of the colonic response without affecting its magnitude. Physostigmine (1 mg/kg) enhanced the bladder and colonic responses and reversed the effects of hexamethonium on these organs. Phentolamine (1 mg/kg) abolished the pressor responses to stimulation of the thoracolumbar sympathetic outflow but did not affect the cardio-accelerator response. |
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Authors:
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J S Gillespie; A Maclaren; D Pollock |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 40 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1970 Oct |
Date Detail:
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Created Date: 1971-02-25 Completed Date: 1971-02-25 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 257-67 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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innervation Animals Atropine / pharmacology Autonomic Fibers, Preganglionic / physiology* Autonomic Nervous System / drug effects Blood Vessels / innervation Cats Colon / innervation Cordotomy Depression, Chemical Electric Stimulation* Electrodes Female Heart / innervation Hexamethonium Compounds / pharmacology Male Methods Phentolamine / pharmacology Physostigmine / pharmacology Rats Spinal Cord / physiology* Urinary Bladder / innervation Vas Deferens / innervation |
| Chemical | |
Reg. No./Substance:
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0/Hexamethonium Compounds; 50-60-2/Phentolamine; 51-55-8/Atropine; 57-47-6/Physostigmine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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