Document Detail


A method for evaluating antianginal drugs in experimental animals: assessment of myocardial ischemia by myocardial pH.
MedLine Citation:
PMID:  2873274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper describes a method by which antianginal drugs can be evaluated in the dog heart in situ. Myocardial pH was measured continuously by a micro glass pH electrode inserted in the left ventricular endocardial layers of the dog anesthetized with pentobarbital. Occlusion of the left anterior descending coronary artery (LAD) decreased myocardial pH, and release of the LAD restored the pH. The myocardial acidosis induced by ischemia was metabolic in nature and accompanied by a decrease in the levels of adenosine triphosphate and creatine phosphate and an increase in the levels of lactate in the myocardium. Drugs were injected intravenously 30 min after incomplete (partial) occlusion ot the LAD, lasting until 60 min after drug injection. Propranolol, atenolol, and sotalol markedly attenuated the myocardial pH that had been decreased by LAD occlusion. Nitroglycerin, diltiazem, and nicorandil also attenuated the pH, but these drugs were less active in attenuating myocardial acidosis. Dipyridamole, nifedipine, and beta-2 adrenoceptor antagonists were least active in this regard. It is concluded that myocardial pH can be used as an indicator of myocardial regional ischemia and utilized for evaluation of antianginal drugs.
Authors:
Y Abiko; K Ichihara; K Sakai; H Sashida; T Ishibashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  8     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-08-18     Completed Date:  1986-08-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  271-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acidosis / metabolism
Adenosine Triphosphate / metabolism
Adrenergic beta-Antagonists / pharmacology
Angina Pectoris / drug therapy*,  etiology
Animals
Coronary Disease / complications,  metabolism*
Dogs
Hydrogen-Ion Concentration
Lactates / metabolism
Lactic Acid
Myocardium / metabolism*
Phosphocreatine / metabolism
Time Factors
Vasodilator Agents / pharmacology
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Lactates; 0/Vasodilator Agents; 50-21-5/Lactic Acid; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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