Document Detail

A method for directly establishing short-term cultures of human gestational choriocarcinoma in vitro.
MedLine Citation:
PMID:  6478446     Owner:  NLM     Status:  MEDLINE    
A procedure is described which offers a method for establishing, without recourse to a serial passage within animal hosts, short-term cultures of human gestational choriocarcinoma in vitro. The method involves the use of either post mortem or surgical biopsy tissue from patients with known choriocarcinomas. The tissues are subsequently sectioned on a freezing microtome and viable tumour selected for explantation in vitro. Radioimmuno assays of culture media supernatant confirm the trophoblastic nature of the cells growing in vitro, cytogenetic analyses of these cultures reveal several aneuploid modes.
E B Ilgren; W B Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  24     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-11-16     Completed Date:  1984-11-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  187-92     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Choriocarcinoma / genetics,  pathology*
Chorionic Gonadotropin / analysis
Culture Techniques / methods
Uterine Neoplasms / genetics,  pathology*
Reg. No./Substance:
0/Chorionic Gonadotropin

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