Document Detail


A method of designing clinical trials for combination drugs.
MedLine Citation:
PMID:  1496194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many pharmaceutical companies are now exploring combination drug therapies as an alternative to monotherapy. Consequently, it is of interest to investigate the simultaneous dose response relationship of two active drugs to select the lowest effective combination. In this paper, we propose a method for designing clinical trials for drug combinations that seems to offer several advantages over the 4 x 3 or even larger factorial studies that have been used to date. In addition, our proposed method provides a convenient formula for calculating the required sample size.
Authors:
J G Pigeon; M D Copenhaver; J P Whipple
Related Documents :
11236214 - Dermatopharmacology of a new combination gel formulation for the topical treatment of a...
21969824 - Lipid emulsion for local anesthetic systemic toxicity.
1980314 - Combination therapy of rheumatoid arthritis--rationale and overview.
24361714 - Predicted multiple selected reaction monitoring to screen activated drug-mediated modif...
15771454 - Genotype dependent qsar for hiv-1 protease inhibition.
22781864 - Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: a lo...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Statistics in medicine     Volume:  11     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-09-08     Completed Date:  1992-09-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1065-74     Citation Subset:  IM    
Affiliation:
Department of Mathematical Sciences, Villanova University, PA 19085.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic / standards*
Dose-Response Relationship, Drug
Drug Therapy, Combination*
Humans
Models, Statistical*
Research Design / standards*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparisons between a new drug and active and placebo controls in an efficacy clinical trial.
Next Document:  Organization and analysis of safety data using a multivariate approach.