| A method for coronary artery calcium scoring using contrast-enhanced computed tomography. | |
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MedLine Citation:
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PMID: 22210533 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Limitations to the coronary calcium score include its requirement for noncontrast imaging and radiation exposure that approaches current methods for contrast-enhanced CT angiography. OBJECTIVES: We sought to derive and validate a method of measuring the coronary artery calcium score (CACS) from standard contrast-enhanced CT, obviating the need for a second non-contrast calcium scan. METHODS: The volume of intramural calcium of >320 HU in major coronary vessels was measured in 90 contrast-enhanced and traditional non-contrast calcium scan pairs. An empiric conversion factor was derived to convert the small voxel contrast-enhanced calcium volume to an Agatston calcium score. The accuracy of this technique was then prospectively validated in 120 consecutive patients undergoing clinical calcium scans and contrasted-enhanced coronary CT. Eleven patients were excluded from analysis because of the prespecified criteria of excessive noise in the contrast-enhanced CT or total coronary artery occlusion. RESULTS: The Pearson correlation of the contrast scan-derived calcium score with the measured CACS was r(2) = 0.99. With standard CACS risk bands, agreement of the contrast-enhanced calcium score estimate with the measured CAC by quadratic weighted κ was 0.96. The 95% limits of agreement (Agatston units) were given by ±(3.2+0.14×CACS+4.44CACS). Inter-observer and intra-observer reliability with the intraclass correlation was 0.99. CONCLUSION: The calcium score can be accurately measured from contrast-enhanced cardiac CT scans with the use of a Hounsfield unit threshold of 320. |
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Authors:
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James M Otton; Jacob T Lønborg; David Boshell; Michael Feneley; Andrew Hayen; Neville Sammel; Ken Sesel; Lourens Bester; Jane McCrohon |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-20 |
Journal Detail:
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Title: Journal of cardiovascular computed tomography Volume: - ISSN: 1876-861X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2012-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101308347 Medline TA: J Cardiovasc Comput Tomogr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Cardiology Department, St Vincent's Hospital, Darlinghurst Sydney 2010, Australia; University of New South Wales, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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