Document Detail


A method for continuously assessing coronary blood flow velocity in the rat.
MedLine Citation:
PMID:  7325249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have developed a directional pulsed-Doppler system to make blood flow velocity measurements in the coronary arteries of the rat. The probe consists of a 1-mm2 crystal mounted in a 6-mm suction cup, which can be attached by vacuum to the vessel without requiring dissection. Recordings of phasic coronary blood flow velocity (CBV) in the rat indicate that 82 +/- 2% (mean +/- SE) of the area under the CBV recording occurs in diastole. CBV increased during an infusion of dipyridamole and changed in parallel with alterations in left-ventricular pressure. To validate the technique we correlated changes in CBV wih changes in microsphere-measured left-ventricular perfusion (range, 20--780 ml/min x 100 g). These two methods of estimating coronary flow correlated closely (r = 0.93). Measurements of phasic CBV in the rat with this Doppler system should permit a detailed characterization of the coronary circulation in many models of disease that have been developed in the rat.
Authors:
R D Wangler; K G Peters; D E Laughlin; R J Tomanek; M L Marcus
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  241     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-03-26     Completed Date:  1982-03-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H816-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity*
Blood Pressure
Coronary Circulation*
Doppler Effect
Heart Rate
Monitoring, Physiologic / instrumentation*
Rats
Rheology
Vasodilation
Grant Support
ID/Acronym/Agency:
HL-00328/HL/NHLBI NIH HHS; HL-14388/HL/NHLBI NIH HHS; HL-20827/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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