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A method for content uniformity determination of atenolol and losartan potassium in combined tablet dosage form.
MedLine Citation:
PMID:  21969756     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
A simple, accurate, rapid, specific and reproducible UV spectrophotometric method was developed for estimation of content uniformity of atenolol and losartan potassium in its combined tablet dosage form. The method involves formation and solving the simultaneous equation using 226.4 and 254 nm as two wavelengths for atenolol and losartan, respectively. Developed method was employed to determine the atenolol and losartan content in ten individual tablet units of five market formulations. Methanol was used as solvent. The method was validated. From the results, it was concluded that all brands are within the content uniformity limit, 85-115%.
Authors:
S A Shah; R B Vyas; B A Vyas; N R Maniyar; R S Chauhan; D R Shah
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pharmaceutical sciences     Volume:  72     ISSN:  1998-3743     ISO Abbreviation:  Indian J Pharm Sci     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2011-10-04     Completed Date:  2011-11-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7809431     Medline TA:  Indian J Pharm Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  792-4     Citation Subset:  -    
Affiliation:
Department of Quality Assurance, Maliba Pharmacy College, Gopal Vidyanagar, Bardoli-Mahuva Road, Tarsadi 394 350, Dist. Surat, Gujarat, India.
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