Document Detail

A method for computing the decision level for samples containing radioactivity in the presence of background.
MedLine Citation:
PMID:  7493804     Owner:  NLM     Status:  MEDLINE    
It is often necessary to make a decision whether or not a sample contains radioactivity in excess of background. The most common procedure is a deterministic approach that compares the result from each sample against a critical level, Lc. Originally Lc was derived from the case where each sample is paired with a blank or control that is known not to contain excess radioactivity. However, most analytic laboratories do not process a blank with each and every sample. Another approach computes Lc using a collection of measurements to form a "well defined" background. This paper presents a method for determining a decision level, L delta, that includes the uncertainties in both the mean and variance of background and how these combine to form uncertainties in estimating the tails of the background distribution. The values of L delta are greater than Lc for a given Type I error. It can be applied whenever the true distribution of background is either normal or log normal. The process is not restricted to counting statistics and is valid for identifying excess contamination of any type providing that unknown samples are processed identically to background samples.
T B Borak; T B Kirchner
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Health physics     Volume:  69     ISSN:  0017-9078     ISO Abbreviation:  Health Phys     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-01-05     Completed Date:  1996-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985093R     Medline TA:  Health Phys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  892-6     Citation Subset:  IM    
Department of Radiological Health Sciences, Colorado State University, Ft. Collins 80523, USA.
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MeSH Terms
Biological Assay
Decision Support Techniques*
Environmental Monitoring
Radiation Monitoring / methods*
Radioisotopes / analysis*
Research / methods*
Sensitivity and Specificity
Reg. No./Substance:

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