Document Detail


A method of calculating total respiratory system compliance from resonant frequency: validity in a rabbit model.
MedLine Citation:
PMID:  2284157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ten anesthetized, tracheotomized, adult rabbits were used to test the validity of a method for calculation of total respiratory system compliance from resonant frequency (Cr). Reference values were obtained during constant flow inflation of the relaxed respiratory system by dividing the volume gain by the related difference in pressure at the airway opening (inflation method compliance, Ci). The animals were connected to a new type of servo-controlled infant ventilator. Besides volume-controlled mechanical ventilation at constant inspiratory flow rate and intermittent mandatory ventilation, there is a negative ventilator resistance mode integrated in this device for resistive unloading (Schulze A, Schaller P, Gehrhardt B, Mädler H-J, Gmyrek D: Pediatr Res 28:79-82, 1990). To measure resonant frequency (fr), the respiratory system was totally unloaded for a short period by a negative ventilator resistance exceeding the combined resistances of the endotracheal tube and airways. This evoked a continuous oscillation at fr. By analogy with electrical circuit theory, Cr was calculated according to C = 1/(4 pi 2.I.fr2) where C is compliance and I is inertance. The inertance of the endotracheal tube is given and that of the bronchial tree was ignored assuming a much greater total cross-sectional area and therefore much lower inertance when compared with the endotracheal tube. Three pairs of Ci - Cr values were obtained from each animal: 1) during intact respiratory muscle activity; 2) after pancuronium relaxation, and 3) after surfactant depletion by saline washout.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
A Schulze; P Schaller; J Dinger; U Winkler; D Gmyrek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  28     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-03-15     Completed Date:  1991-03-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  599-602     Citation Subset:  IM    
Affiliation:
Children's Hospital, Department of Neonatology, Dresden, East Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Lung Compliance / physiology*
Methods
Models, Biological
Rabbits
Respiratory Function Tests / methods
Respiratory Mechanics / physiology

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