| A method of adjusting SUV for injection-acquisition time differences in (18) F-FDG PET Imaging. | |
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MedLine Citation:
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PMID: 21796499 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: A time normalisation method of tumour SUVs in (18) F-FDG PET imaging is proposed that has been verified in lung cancer patients. METHODS: A two-compartment model analysis showed that, when SUV is not corrected for (18) F physical decay (SUV(uncorr)), its value is within 5% of its peak value (t = 79 min) between 55 and 110 min after injection, in each individual patient. In 10 patients, each with 1 or more malignant lesions (n = 15), two PET acquisitions were performed within this time delay, and the maximal SUV of each lesion, both corrected and uncorrected, was assessed. RESULTS: No significant difference was found between the two uncorrected SUVs, whereas there was a significant difference between the two corrected ones: mean differences were 0.04 ± 0.22 and 3.24 ± 0.75 g.ml(-1), respectively (95% confidence intervals). Therefore, a simple normalisation of decay-corrected SUV for time differences after injection is proposed: SUV(N) = 1.66*SUV(uncorr), where the factor 1.66 arises from decay correction at t = 79 min. CONCLUSIONS: When (18) F-FDG PET imaging is performed within the range 55-110 min after injection, a simple SUV normalisation for time differences after injection has been verified in patients with lung cancer, with a ±2.5% relative measurement uncertainty. |
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Authors:
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Eric Laffon; Henri de Clermont; Roger Marthan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-28 |
Journal Detail:
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Title: European radiology Volume: - ISSN: 1432-1084 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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CHU de Bordeaux, Hôpital du Haut Lévèque, 33604, Pessac, France, elaffon@u-bordeaux2.fr. |
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