Document Detail


On metformin's potential to prevent preterm delivery in women with polycystic ovary syndrome - an epi-analysis.
MedLine Citation:
PMID:  23006146     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Our aim was to reevaluate if metformin may reduce late miscarriage/preterm delivery, preeclampsia and gestational diabetes in women with polycystic ovary syndrome (PCOS). We performed an epi-analysis of two randomized controlled trials. The participants were 313 PCOS women with singleton pregnancies, aged 18-42 years. They were randomized to metformin or placebo treatment from first trimester until delivery. We analyzed the prevalence of late miscarriage/ preterm delivery, preeclampsia and gestational diabetes both according intention-to-treat principal and per protocol analysis. The metformin-treated patients had less late miscarriage/preterm delivery; 5 (3%) vs. 18 (11%) in the placebo group (p<0.01). There was no difference in the prevalence of gestational diabetes and preeclampsia between the metformin and the placebo group. In this epi-analysis, metformin treatment during pregnancy seems to reduce early delivery in women with PCOS. We believe further randomized studies should be performed, before firm conclusions can be drawn.
Authors:
Eszter Vanky; Francis DE Zegher; Marta Díaz; Lourdes Ibáñez; Sven M Carlsen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-24
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology.
Affiliation:
Department of Obstetrics and Gynecology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway Institute for Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway Pediatric Endocrinology, University Hospital Gasthuisberg, Leuven, Belgium Endocrinology Unit, Hospital Sant Joan de Déu, University of Barcelona, Esplugues, Barcelona, Spain Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Madrid, Spain Unit for Applied Clinical Research, Institute of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway Department of Endocrinology, St. Olav's Hospital, Trondheim, University Hospital, Trondheim, Norway.
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