| Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome? | |
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MedLine Citation:
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PMID: 17145645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insulin resistance is an important pathophysiological feature of the polycystic ovary syndrome (PCOS). Insulin resistance and its compensatory hyperinsulinemia contribute to the anovulation, hyperandrogenism, infertility and early pregnancy loss suffered by women with PCOS. Current evidence supports the role of metformin in the treatment of anovulation in PCOS, both in monotherapy and concomitantly with clomiphene in clomiphene-resistant patients. In addition, novel evidence suggests that insulin sensitizers may also play a role in reducing the risk of early pregnancy loss. The insulin-sensitizing agents available commercially include metformin, rosiglitazone and pioglitazone. Compared with the thiozolidinediones, metformin is the agent that has been most frequently studied in PCOS, and has the most favorable pregnancy safety profile. In conclusion, there is strong evidence supporting the use of metformin as a primary ovulatory agent in women with PCOS. |
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Authors:
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Kai I Cheang; Susmeeta T Sharma; John E Nestler |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 22 ISSN: 0951-3590 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-12-05 Completed Date: 2007-04-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 595-604 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298-0111, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anovulation
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therapy Clinical Trials as Topic Female Fertility Agents, Female / pharmacology*, therapeutic use* Humans Infertility, Female / therapy Insulin Resistance Metformin / therapeutic use* Polycystic Ovary Syndrome / drug therapy* Pregnancy Pregnancy Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fertility Agents, Female; 657-24-9/Metformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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