| A metering rotary nanopump for microfluidic systems. | |
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MedLine Citation:
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PMID: 20959938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe the design, fabrication, and testing of a microfabricated metering rotary nanopump for the purpose of driving fluid flow in microfluidic devices. The miniature peristaltic pump is composed of a set of microfluidic channels wrapped in a helix around a central camshaft in which a non-cylindrical cam rotates. The cam compresses the helical channels to induce peristaltic flow as it is rotated. The polydimethylsiloxane (PDMS) nanopump design is able to produce intermittent delivery or removal of several nanolitres of fluid per revolution as well as consistent continuous flow rates ranging from as low as 15 nL min(-1) to above 1.0 µL min(-1). At back pressures encountered in typical microfluidic devices, the pump acts as a high impedance flow source. The durability, biocompatibility, ease of integration with soft-lithographic fabrication, the use of a simple rotary motor instead of multiple synchronized pneumatic or mechanical actuators, and the absence of power consumption or fluidic conductance in the resting state all contribute to a compact pump with a low cost of fabrication and versatile implementation. This suggests that the pump design may be useful for a wide variety of biological experiments and point of care devices. |
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Authors:
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Scott G Darby; Matthew R Moore; Troy A Friedlander; David K Schaffer; Ron S Reiserer; John P Wikswo; Kevin T Seale |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-20 |
Journal Detail:
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Title: Lab on a chip Volume: 10 ISSN: 1473-0197 ISO Abbreviation: Lab Chip Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-10 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128948 Medline TA: Lab Chip Country: England |
Other Details:
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Languages: eng Pagination: 3218-26 Citation Subset: IM |
Affiliation:
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Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, VU Station B, 351807, Nashville, TN, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Automation Biocompatible Materials / chemistry Dimethylpolysiloxanes / chemistry Equipment Design Membranes, Artificial* Microfluidic Analytical Techniques* Nanotechnology / methods Perfusion Pressure Silicon / chemistry |
| Grant Support | |
ID/Acronym/Agency:
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1RC2DA028981-01/DA/NIDA NIH HHS; U01AI061223-05/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Dimethylpolysiloxanes; 0/Membranes, Artificial; 63148-62-9/baysilon; 7440-21-3/Silicon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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