Document Detail


A metastatic melanoma with an unusual immunophenotypic profile.
MedLine Citation:
PMID:  17414440     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The most commonly used melanocytic markers are S100, HMB45, Melan-A, or MART-1 and tyrosinase. Melanoma with complete, concordant loss of these markers has not been reported. We report a case of metastatic melanoma with complete loss of staining for S100, HMB45, Melan-A, and tyrosinase. Interestingly, both the primary melanoma and its metastasis were strongly positive for CD99.
Authors:
Zhenqiang Gao; Albert Stanek; Sheng Chen
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  29     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-06     Completed Date:  2007-06-12     Revised Date:  2010-09-01    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  169-71     Citation Subset:  IM    
Affiliation:
Department of Pathology, Albert Einstein College of Medicine North Shore Long Island Jewish Health System, New Hyde Park, NY 11040, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antigens, CD / analysis
Antigens, CD56 / analysis
Antigens, Neoplasm / analysis
Cell Adhesion Molecules / analysis
Down-Regulation
Humans
Immunohistochemistry
Immunophenotyping*
Lymph Nodes / pathology
Lymphatic Metastasis
Male
Melanoma / chemistry*,  diagnosis,  enzymology,  immunology,  pathology
Monophenol Monooxygenase / analysis
Neoplasm Proteins / analysis
S100 Proteins / analysis
Skin Neoplasms / chemistry*,  diagnosis,  enzymology,  immunology,  pathology
Tumor Markers, Biological / analysis*
Vimentin / analysis
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD56; 0/Antigens, Neoplasm; 0/CD99 protein, human; 0/Cell Adhesion Molecules; 0/MART1 antigen; 0/Neoplasm Proteins; 0/S100 Proteins; 0/Tumor Markers, Biological; 0/Vimentin; 0/melanoma-specific antigens; EC 1.14.18.1/Monophenol Monooxygenase

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