Document Detail


The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily.
MedLine Citation:
PMID:  8858107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have cloned proteins that interact with the nuclear orphan receptor RZR beta using the yeast two-hybrid system. We identified, amongst a number of other genes, the nucleoside diphosphate kinase (NDPK)-2 also known as Nm23-2, c-myc regulatory factor PuF and differentiation inhibitory factor, RZR beta specifically interacts with Nm23-2 but not with the closely related tumor metastasis suppressor candidate gene product Nm23-1. In contrast ROR alpha interacts with both Nm23 proteins. These findings were corroborated by in vitro interaction assays based on GST-pulldown experiments. With-n-myc we propose a candidate gene regulated by ROR alpha/RZR beta and Nm23, based on the finding that the respective DNA binding sites in the first intron are conserved in several mammalian species.
Authors:
G Paravicini; M Steinmayr; E André; M Becker-André
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  227     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-11-25     Completed Date:  1996-11-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  82-7     Citation Subset:  IM    
Affiliation:
Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development S.A, Plan-les-Ouates, Switzerland.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/M12731;  X63281;  Y00664
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Genes, myc
Humans
Mice
Molecular Sequence Data
Monomeric GTP-Binding Proteins*
NM23 Nucleoside Diphosphate Kinases
Nucleoside-Diphosphate Kinase*
Protein Binding
Rats
Receptors, Cytoplasmic and Nuclear / metabolism*
Sequence Homology, Nucleic Acid
Substrate Specificity
Transcription Factors / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/NM23 Nucleoside Diphosphate Kinases; 0/Receptors, Cytoplasmic and Nuclear; 0/Transcription Factors; EC 2.7.4.6/NME1 protein, human; EC 2.7.4.6/Nme1 protein, mouse; EC 2.7.4.6/Nucleoside-Diphosphate Kinase; EC 3.6.5.2/Monomeric GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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