| Is metalloproteinase-7 specific for idiopathic pulmonary fibrosis? | |
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MedLine Citation:
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PMID: 18071010 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Matrix metalloproteinase (MMP)-7 was reported to be a key molecule in the pathogenesis of idiopathic pulmonary fibrosis (IPF) based on the result of microarray analysis and knockout mice. However, the role of MMP-7 has not been determined in other types of idiopathic interstitial pneumonia (IIP). The aim of this study was to investigate the role of MMP-7 in IIP by comparing its expression in usual interstitial pneumonia (UIP) and cryptogenic organizing pneumonia (COP). METHODS: Levels of MMP and tissue inhibitors of metalloproteinase in BAL fluid and their expression on lung tissues were compared between normal control subjects (n = 5) and the patients with IPF (n = 6) and COP (n = 11). RESULTS: There was no significant difference in BAL fluid MMP-7 levels between UIP and COP, although it was higher in both diseases compared to normal control subjects. Furthermore, the pattern and the degree of MMP-7 expression in lung tissues were also similar in both IPF and COP, whereas MMP-2 level was higher in COP and MMP-9 level was higher in IPF. CONCLUSION: MMP-7 seems to play an important role in the pathogenesis of not only IPF but also COP; therefore, it may not be the key factor determining the prognosis or reversibility of IIPs. |
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Authors:
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Jin Won Huh; Dong Soon Kim; Yeon-Mok Oh; Tae Sun Shim; Chae Man Lim; Sang Do Lee; Yunsuck Koh; Woo Sung Kim; Won Dong Kim; Kyu Rae Kim |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-12-10 |
Journal Detail:
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Title: Chest Volume: 133 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-07 Completed Date: 2008-06-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 1101-6 Citation Subset: AIM; IM |
Affiliation:
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Division of Pulmonary and Critical Care Medicine, Asan Medical Center, College of Medicine, University of Ulsan, 388-1, Poongnap-dong, Songpa-gu, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Markers / metabolism Biopsy Bronchoalveolar Lavage Fluid / chemistry Diagnosis, Differential Enzyme-Linked Immunosorbent Assay Female Humans Immunohistochemistry Lung / enzymology, pathology Lung Diseases, Interstitial / enzymology, pathology Male Matrix Metalloproteinase 7 / biosynthesis* Middle Aged Prognosis Pulmonary Fibrosis / enzymology*, pathology Severity of Illness Index Tissue Inhibitor of Metalloproteinases / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Tissue Inhibitor of Metalloproteinases; EC 3.4.24.23/Matrix Metalloproteinase 7 |
| Comments/Corrections | |
Comment In:
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Chest. 2008 May;133(5):1058-60
[PMID:
18460508
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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