Document Detail

A metalloprotease prepares the way.
MedLine Citation:
PMID:  10508599     Owner:  NLM     Status:  MEDLINE    
In the nematode Caenorhabditis elegans gonad shape and size is determined by the migration of a leader cell, which is at the tip of the growing gonad arm. A metalloprotease secreted by the leader cell has recently been found to play an essential role in this process, preparing the way ahead for the cell's migration.
D G Moerman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current biology : CB     Volume:  9     ISSN:  0960-9822     ISO Abbreviation:  Curr. Biol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  2000-02-14     Completed Date:  2000-02-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  R701-3     Citation Subset:  IM    
Department of Zoology 6270 University Boulevard University of British Columbia Vancouver, British Columbia, Canada V6T 1Z4,.
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MeSH Terms
ADAM Proteins
Basement Membrane
Caenorhabditis elegans / enzymology*,  genetics,  growth & development,  physiology
Caenorhabditis elegans Proteins*
Cell Lineage
Cell Movement / physiology*
Disintegrins / genetics
Embryonal Carcinoma Stem Cells
Extracellular Matrix / physiology
Extracellular Matrix Proteins / physiology*
Genes, Reporter
Gonads / cytology,  growth & development
Helminth Proteins / genetics,  physiology*
Matrix Metalloproteinase 2 / physiology
Metalloendopeptidases / genetics,  physiology*
Models, Biological
Morphogenesis / genetics,  physiology*
Multigene Family
Muscle Proteins / physiology
Neoplasm Metastasis
Neoplastic Stem Cells / cytology
Peptide Fragments / genetics
Procollagen / genetics
Recombinant Fusion Proteins / physiology
Species Specificity
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Disintegrins; 0/Extracellular Matrix Proteins; 0/Helminth Proteins; 0/Muscle Proteins; 0/Peptide Fragments; 0/Procollagen; 0/Recombinant Fusion Proteins; 0/procollagen Type I N-terminal peptide; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/Adamts1 protein, mouse; EC 3.4.24.-/GON-1 protein, C elegans; EC 3.4.24.-/Metalloendopeptidases; EC Metalloproteinase 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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