Document Detail

A metabolomics view on gut microbiome modulation by polyphenol-rich foods.
MedLine Citation:
PMID:  22905879     Owner:  NLM     Status:  Publisher    
Health is influenced by genetic, lifestyle, and diet determinants, therefore nutrition plays an essential role in health management. Still, the substantiation of nutritional health benefits is challenged by the intrinsic macro- and micronutrient complexity of foods and individuals' responses. Evidence of healthy effects of food requires not only new strategies to stratify populations according to their metabolic requirements, but also to predict and measure individual responses to dietary intakes. The influence of the gut microbiome and its interaction with the host is pivotal to understand nutrition and metabolism. Thus, the modulation of the gut microbiome composition by alteration of food habits has potentialities in health improvement or even disease prevention. Dietary polyphenols are naturally occurring constituents in vegetables and fruits, including coffee and cocoa. They are commonly associated to health benefits, although mechanistic evidence in vivo is not yet fully understood. Polyphenols are extensively metabolised by gut bacteria into a complex series of end-products which support a significant effect on the functional ecology of symbiotic partners which can affect the host physiology. This review reports recent nutritional metabolomics inspections of gut microbiota-host metabolic interactions with a particular focus on the co-metabolism of cocoa and coffee polyphenols.
Sofia Moco; François-Pierre Martin; Serge Rezzi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-21
Journal Detail:
Title:  Journal of proteome research     Volume:  -     ISSN:  1535-3907     ISO Abbreviation:  J. Proteome Res.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128775     Medline TA:  J Proteome Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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