Document Detail


The metabolism of thionicotinamide in the rat.
MedLine Citation:
PMID:  1839279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The metabolism of the thioamide, thionicotinamide, in the male Wistar rat is described. Thionicotinamide was shown to be metabolised to inorganic sulphate, thionicotinamide S-oxide and also N1-methylnicotinamide, which arises from N-methylation of nicotinamide via desulphuration of the parent thioamide. At 24 hours from dosing about 35% of the dose had been excreted as inorganic sulphate and 20.5% as the S-oxide metabolite. Three metabolites, detected by their fluorescence under UV light, have not been positively identified but are postulated to be pyridones, resulting from ring oxidation, by analogy with other thioamides. S-Oxidation is an important metabolic pathway as it may give rise to toxic intermediates.
Authors:
M J Ruse; R H Waring
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug metabolism and drug interactions     Volume:  9     ISSN:  0792-5077     ISO Abbreviation:  Drug Metabol Drug Interact     Publication Date:  1991  
Date Detail:
Created Date:  1992-04-20     Completed Date:  1992-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904736     Medline TA:  Drug Metabol Drug Interact     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  123-37     Citation Subset:  IM    
Affiliation:
School of Biochemistry, University of Birmingham, Edgbaston, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Male
Niacinamide / analogs & derivatives*,  metabolism,  urine
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
4621-66-3/thionicotinamide; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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