Document Detail

The metabolism of pyrene by rat liver microsomes and the influence of various mono-oxygenase inducers.
MedLine Citation:
PMID:  7090418     Owner:  NLM     Status:  MEDLINE    
1. Pyrene metabolite g.l.c. profiles were recorded and metabolites identified by mass spectrometry. 2. Pyrene is metabolized by liver microsomes of untreated rats to 1-hydroxypyrene, 4,5-dihydroxy-4,5-dihydropyrene, two different diphenols and a triol, tentatively identified as 1,4,5-trihydroxy-4,5-dihydropyrene. 3. Pretreatment with phenobarbital or polychlorinated biphenyls favours oxidation at the K-region, whereas cytochrome P-448 inducers stimulate oxidation at the non-K-region of pyrene. 4. 1-Hydroxypyrene does not inhibit pyrene oxidation. 5. Pyrene diphenols are formed by secondary oxidation of 1-hydroxypyrene. 6. Triols are formed from dihydrodiols by secondary oxidation.
J Jacob; G Grimmer; G Raab; A Schmoldt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  12     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-08-14     Completed Date:  1982-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  45-53     Citation Subset:  IM    
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MeSH Terms
Enzyme Induction / drug effects
Microsomes, Liver / metabolism*
Mixed Function Oxygenases / biosynthesis*
Oxidoreductases / biosynthesis*
Pyrenes / metabolism*
Rats, Inbred Strains
Reg. No./Substance:
0/Pyrenes; 129-00-0/pyrene; EC 1.-/Mixed Function Oxygenases; EC 1.-/Oxidoreductases

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