Document Detail

The metabolism and motility of human spermatozoa in the presence of steroid hormones and synthetic progestagens.
MedLine Citation:
PMID:  690978     Owner:  NLM     Status:  MEDLINE    
The metabolism and motility of human ejaculated spermatozoa incubated in vitro with steroids were studied. Progesterone and norethynodrel depressed the respiration, glycolytic metabolism and the motility of washed spermatozoa. Lynoestrenol did not affect the respiration or glycolysis of the spermatozoa, but did inhibit motility. Oestradiol did not cause any consistent alteration of the sperm metabolism, and did not affect the motility. Progesterone and norethynodrel appeared to act on the plasma membrane of human spermatozoa to increase its permeability and hence to facilitate the loss of essential cofactors required for the glycolytic and oxidative processes.
R V Hyne; R N Murdoch; B Boettcher
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  53     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-11-18     Completed Date:  1978-11-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  315-22     Citation Subset:  IM    
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MeSH Terms
Energy Metabolism / drug effects
Estradiol / pharmacology*
Lynestrenol / pharmacology*
Norethynodrel / pharmacology*
Progesterone / pharmacology*
Sperm Motility / drug effects*
Spermatozoa / drug effects,  metabolism*
Reg. No./Substance:
50-28-2/Estradiol; 52-76-6/Lynestrenol; 57-83-0/Progesterone; 68-23-5/Norethynodrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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