Document Detail

The metabolism of the isolated artificially perfused guinea pig placenta. I. Excretion of hydrogen ions, ammonia, carbon dioxide and lactate, and the consumption of oxygen and glucose.
MedLine Citation:
PMID:  6809927     Owner:  NLM     Status:  MEDLINE    
In the isolated, perfused guinea pig placenta glucose seems to be a major nutrient of energy metabolism, because the excreted amounts of carbon dioxide and lactate can be explained solely by the catabolism of glucose. In steady state experiments hydrogen ions, ammonia, lactate and carbon dioxide are excreted for at least 90 minutes in rather constant amounts. The production of lactate shows no significant dependence on the glucose concentration in the perfusion fluid. The guinea pig placenta seems to cover its energy requirement mainly by means of anaerobic glycolysis. Of the utilized glucose 76% are metabolized anaerobically. The placenta produces significant quantities of lactate, although it is well oxygenated. A reduction of the oxygen tension in the perfusion fluid does not result in an increase of the production of lactate. Of the hydrogen ions excreted nearly 50% are excreted as ammonia. Although the excreted amounts are small compared with the known transfer rates, they have to be taken into consideration, when studying transplacental transfers of these metabolites.
M H Carstensen; H P Leichtweiss; H Schröder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  10     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1982  
Date Detail:
Created Date:  1982-10-21     Completed Date:  1982-10-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  147-53     Citation Subset:  IM    
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MeSH Terms
Ammonia / metabolism
Biological Transport
Carbon Dioxide / metabolism
Glucose / metabolism
Guinea Pigs
Hydrogen-Ion Concentration
Lactates / metabolism
Oxygen Consumption
Placenta / metabolism*
Reg. No./Substance:
0/Lactates; 124-38-9/Carbon Dioxide; 50-99-7/Glucose; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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