| The metabolism of an exogenous lipid source during septic shock in the puppy. | |
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MedLine Citation:
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PMID: 6441006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Septic shock induces physiologic and hemodynamic responses that may alter the host's ability to metabolize an exogenous source of lipids. The present study examined the metabolic changes occurring during septic shock in the young animal receiving an intravenous fat emulsion. Five 8-wk-old male Beagle puppies were studied. Each animal served as his own control twice, during which time 14C-palmitic acid alone or with a 10% fat emulsion (Liposyn) was administered. Septic shock (cardiac output less than 50% of control) was induced with an intravenous bolus of live Escherichia coli. During shock the puppies received intravenous 14C-palmitic acid and Liposyn. The mean respiratory quotient for the shock dogs (0.96 +/- 0.01) was significantly (p less than 0.05) higher than that of the controls (0.83 +/- 0.06). The amount of expired 14CO2 was 25.0 +/- 15.9% for the shock animals, 53.9 +/- 28.1% for the Liposyn controls, and 75.7 +/- 30.5% for the controls receiving only 14C-palmitic acid (these differences are all significant, p less than 0.05). After the onset of shock, serum triglyceride levels peaked within 2 min at 851 +/- 540 mg/100 ml and remained elevated at 333 +/- 213 mg/100 ml. Triglyceride levels in the Liposyn control animals returned to baseline values (54 +/- 13 mg/100 ml) at the end of the 4-hr experimental period. Free fatty acids in the shock dogs reached a maximal level of 1.44 +/- 0.09 mEq/liter at 1 hr and remained at this elevated value for a significantly longer period of time than in the Liposyn control puppies. Glycerol value followed a similar pattern and cholesterol remain unchanged.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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A G Coran; R A Drongowski; G S Lee; M D Klein; J R Wesley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: 8 ISSN: 0148-6071 ISO Abbreviation: JPEN J Parenter Enteral Nutr Publication Date: 1984 Nov-Dec |
Date Detail:
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Created Date: 1985-02-27 Completed Date: 1985-02-27 Revised Date: 2007-02-21 |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 652-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Dogs Escherichia coli Infections / metabolism*, therapy Fat Emulsions, Intravenous / administration & dosage* Fatty Acids, Nonesterified / blood Glycerol / blood Insulin / blood Lipid Metabolism* Parenteral Nutrition* Shock, Septic / metabolism*, therapy Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fat Emulsions, Intravenous; 0/Fatty Acids, Nonesterified; 0/Triglycerides; 11061-68-0/Insulin; 56-81-5/Glycerol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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