Document Detail


The metabolism of ethylbenzene hydroperoxide in the rat.
MedLine Citation:
PMID:  6673374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ethyl[14C]benzene hydroperoxide administered orally to female rats (30 mg/kg) is rapidly absorbed and metabolized. Most of the administered compound (81%) is eliminated in the 0-24 h urine. Major metabolites include mandelic acid (23%), hippuric acid (34%) and 1-phenylethyl glucuronide (4%). Ethyl[14C]benzene is metabolized via 1-phenylethanol to the same mixture of metabolites as obtained with the hydroperoxide. Biotransformations of the hydroperoxide and their likely biochemical mechanisms are discussed.
Authors:
I J Climie; D H Hutson; G Stoydin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  13     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1984-05-21     Completed Date:  1984-05-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  611-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoradiography
Biotransformation
Carbon Radioisotopes
Chromatography, Thin Layer
Female
Metabolic Detoxication, Drug
Peroxides / metabolism*,  urine
Rats
Rats, Inbred Strains
Tissue Distribution
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Peroxides; 3071-32-7/ethylbenzene hydroperoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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