Document Detail


The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites.
MedLine Citation:
PMID:  12592675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Berry extracts rich in anthocyanins have been linked to protective effects including the modulation of age-related neurological dysfunction and the improvement of the resistance of red blood cells against oxidative stress in vitro. In this study the bioavailability, metabolism and elimination of polyphenols from blackcurrant juice, rich in anthocyanins, flavonols, and hydroxycinnamates, were investigated. The four major native anthocyanidin glycosides of blackcurrant juice, delphinidin-3-glucoside, delphinidin-3-rutinoside, cyanidin-3-glucoside and cyanidin-3-rutinoside, were detected and identified in low amounts by HPLC and LC-MS in plasma and urine post-ingestion. Elimination of the anthocyanins was fast (maximum excretion after 1 h) and plasma levels (0-128.6 nmol/l) and total urinary exretion (0.07-1.35 mg; 0.007-0.133% of the dose ingested) were low. Most significantly, of the hydroxycinnamates, conjugated and free ferulic, isoferulic, p-coumaric, sinapic and vanillic acids were identified in plasma and urine, using GC-MS techniques. Quercetin and kaempferol (as glucuronides) and the proposed colonic metabolite of quercetin, 3-hydroxyphenylacetic acid, were detectable in a minority of subjects. Increased daily urinary hippuric, 4-hydroxyhippuric and 3-hydroxyhippuric acid levels were also observed post-ingestion in all volunteers.
Authors:
Andreas R Rechner; Gunter Kuhnle; Henglong Hu; Andrea Roedig-Penman; Maarten H van den Braak; Kevin P Moore; Catherine A Rice-Evans
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical research     Volume:  36     ISSN:  1071-5762     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2003-02-20     Completed Date:  2003-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1229-41     Citation Subset:  IM    
Affiliation:
Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, Guy's, King's and St. Thomas's School of Biomedical Sciences, King's College London, Guy's Campus, Hodgkin Building-3rd Floor, London SE1 9RT, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anthocyanins / blood,  pharmacokinetics,  urine
Biological Availability
Biotransformation
Chromatography, High Pressure Liquid
Diet*
Female
Flavonoids*
Fruit
Gastric Juice / metabolism
Glucuronides / metabolism*
Humans
Male
Mass Spectrometry
Phenols / metabolism*
Polymers / metabolism*
Chemical
Reg. No./Substance:
0/Anthocyanins; 0/Flavonoids; 0/Glucuronides; 0/Phenols; 0/Polymers

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