Document Detail


The metabolism of anabolic-androgenic steroids in the greyhound.
MedLine Citation:
PMID:  23534422     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity. In order to better police their use in Australian and New Zealand greyhound racing, thorough metabolic studies have been carried out on a range of registered human and veterinary AASs available in the region. Results: Canine metabolic data are presented for the AASs boldenone, danazol, ethylestrenol, mesterolone, methandriol, nandrolone and norethandrolone. The principal Phase I metabolic processes observed were the reduction of A-ring unsaturations and/or 3-ketones with either 3α,5β- or 3β,5α-stereochemistry, the oxidation of secondary 17β-hydroxyl groups and 16α-hydroxylation. The Phase II β-glucuronylation of sterol metabolites was extensive. Conclusion: The presented data have enabled the effective analysis of AASs and their metabolites in competition greyhound urine samples.
Authors:
Andrew R McKinney; Adam T Cawley; E Bruce Young; Carmel M Kerwick; Karen Cunnington; Rhiannon T Stewart; Joseph I Ambrus; Anthony C Willis; Malcolm D McLeod
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioanalysis     Volume:  5     ISSN:  1757-6199     ISO Abbreviation:  Bioanalysis     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101512484     Medline TA:  Bioanalysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  769-81     Citation Subset:  IM    
Affiliation:
Australian Racing Forensic Laboratory. Currently with the Department of the President's Affairs, PO Box 17292, Al Ain, United Arab Emirates. amckinney@mscpc.ae.
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