Document Detail

A metabolic throttle regulates the epigenetic state of rDNA.
MedLine Citation:
PMID:  18485866     Owner:  NLM     Status:  MEDLINE    
The synthesis of ribosomal RNA (rRNA) is carefully tuned to match nutritional conditions. In this issue, Murayama et al. (2008) describe a mechanism that couples the energy status of the cell to heterochromatin formation and silencing of rRNA genes. They show that an altered NAD(+)/NADH ratio in response to glucose starvation regulates the silencing activity of eNoSC, a complex consisting of the NAD(+)-dependent histone deacetylase SIRT1, the histone methyltransferase SUV39H1, and a new protein called nucleomethylin (NML). These results suggest a mechanism that links cell physiology to rDNA silencing, which in turn is a prerequisite for nucleolar integrity and cell survival.
Ingrid Grummt; Andreas G Ladurner
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Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  Cell     Volume:  133     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  577-80     Citation Subset:  IM    
Department of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
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MeSH Terms
Cell Nucleolus / metabolism
Cell Survival
DNA, Ribosomal / genetics*
Energy Metabolism*
Epigenesis, Genetic*
Histone-Lysine N-Methyltransferase / metabolism
NAD / metabolism
Protein Methyltransferases
Sirtuins / metabolism
Reg. No./Substance:
0/DNA, Ribosomal; 53-84-9/NAD; EC 2.1.1.-/Protein Methyltransferases; EC 2.1.1.-/histone methyltransferase; EC N-Methyltransferase; EC 3.5.1.-/Sirtuins
Comment On:
Cell. 2008 May 16;133(4):627-39   [PMID:  18485871 ]

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