| A metabolic throttle regulates the epigenetic state of rDNA. | |
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MedLine Citation:
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PMID: 18485866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthesis of ribosomal RNA (rRNA) is carefully tuned to match nutritional conditions. In this issue, Murayama et al. (2008) describe a mechanism that couples the energy status of the cell to heterochromatin formation and silencing of rRNA genes. They show that an altered NAD(+)/NADH ratio in response to glucose starvation regulates the silencing activity of eNoSC, a complex consisting of the NAD(+)-dependent histone deacetylase SIRT1, the histone methyltransferase SUV39H1, and a new protein called nucleomethylin (NML). These results suggest a mechanism that links cell physiology to rDNA silencing, which in turn is a prerequisite for nucleolar integrity and cell survival. |
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Authors:
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Ingrid Grummt; Andreas G Ladurner |
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Publication Detail:
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Type: Comment; Journal Article; Review |
Journal Detail:
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Title: Cell Volume: 133 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-19 Completed Date: 2008-06-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 577-80 Citation Subset: IM |
Affiliation:
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Department of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. i.grummt@dkfz-heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Nucleolus / metabolism Cell Survival DNA, Ribosomal / genetics* Energy Metabolism* Epigenesis, Genetic* Histone-Lysine N-Methyltransferase / metabolism Humans NAD / metabolism Protein Methyltransferases Sirtuins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/DNA, Ribosomal; 53-84-9/NAD; EC 2.1.1.-/Protein Methyltransferases; EC 2.1.1.-/histone methyltransferase; EC 2.1.1.43/Histone-Lysine N-Methyltransferase; EC 3.5.1.-/Sirtuins |
| Comments/Corrections | |
Comment On:
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Cell. 2008 May 16;133(4):627-39
[PMID:
18485871
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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