Document Detail

Is metabolic syndrome related with coronary artery disease severity and complexity: An observational study about IDF and AHA/NHLBI metabolic syndrome definitions?
MedLine Citation:
PMID:  24142676     Owner:  NLM     Status:  Publisher    
BACKGROUND: The aim of the present study was to assess the association between metabolic syndrome (MS) and coronary artery disease (CAD) complexity assessed by SYNTAX score (SS) and severity in non-diabetic patients with stable CAD whom underwent coronary angiography and to evaluate whether the MS defined by different definitions including International Diabetes Federation (IDF) and (American Heart Association/National Heart Lung Blood Institute) AHA/NHLBI guidelines similarly correlated with SS.
METHODS: The present study is cross sectional and observational with prospective inclusion of 248 consecutive patients (157 male) who underwent coronary angiography due to stable coronary artery disease.
RESULTS: The prevalence of MS was 54.4% according to IDF definition and 50.4% according to AHA/NHLBI definition. MS score according to IDF definitions (r=0.446, p<0.001), MS score according to AHA/NHLBI definitions (r=0.341, p<0.001) were moderately correlated with SS. In Fisher r to z transformation test the correlations of the presence of MS according to IDF and AHA/NHLBI definitions with SS was not statistically significant (p=0.168, z=-1.38). The systolic blood pressure (p<0.001, B=0.354, CI95%=-0.308-0.228), diastolic blood pressure (p=0.006, B=-0.194, CI95%=-0.333- -0.056), age (p=0.014, B=0.147, CI95%=0.029-0.264), left ventricular ejection fraction (p=0.031, B=-0.150, CI95%=-0.286- -0.014), waist/hip circumference (p<0.001, B=45.713, CI95%=23.235-68.1919) and log10 high density lipoprotein (p<0.001, B=-22.209, CI95%=-33.298- -11.119) were the independent predictors of SS in linear regression analysis.
CONCLUSION: Metabolic syndrome is associated with the presence and complexity of CAD. Besides the presence of discrepancy about the limits of waist circumference, both IDF and AHA/NHLBI criteria were similarly correlated with CAD complexity.
Ahmet Cağrı Aykan; Ilker Gül; Ezgi Kalaycıoğlu; Tayyar Gökdeniz; Engin Hatem; Umit Menteşe; Banu Sahin Yıldız; Mustafa Yıldız
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-21
Journal Detail:
Title:  Cardiology journal     Volume:  -     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Ahi Evren Chest Cardiovascular Surgery Education and Research Hospital.
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