Document Detail

The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland.
MedLine Citation:
PMID:  18323501     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Limited information is available on the role of the metabolic syndrome (MetS) to predict stroke. We investigated the relationship of the MetS and its single components, defined by 6 different criteria, with stroke in a prospective population-based study. METHODS: The MetS was defined according to the World Health Organization, the European Group for the Study of Insulin Resistance, the National Cholesterol Education Program (NCEP), the American College of Endocrinology, the International Diabetes Federation, and the American Heart Association (updated NCEP) criteria. We investigated the relationship of the MetS with stroke using Cox regression analyses in 991 Finnish subjects without diabetes, aged 65 to 74 years at baseline, and followed-up for 14 years. RESULTS: The MetS defined by the World Health Organization, European Group for the Study of Insulin Resistance, NCEP, International Diabetes Federation, and updated NCEP criteria was significantly associated with incident stroke (fatal and nonfatal) when adjusted for confounding variables (HR, 1.52 to 1.72). After exclusion of subjects with myocardial infarction, these 5 definitions still predicted stroke (HR, 1.49 to 1.80). Of the single components of the MetS, the following predicted stroke in multivariable models when subjects with myocardial infarction were excluded: impaired glucose tolerance (2-hour glucose in an oral glucose tolerance test, 7.8 to 11.0 mmol/L) by the World Health Organization and American College of Endocrinology criteria (HR, 1.66); insulin resistance (HR, 1.60) by the European Group for the Study of Insulin Resistance criteria; and central obesity (HR, 1.52) by the NCEP criteria. CONCLUSIONS: The MetS defined by the 6 criteria except for the American College of Endocrinology definition predicts stroke in elderly subjects. However, impaired glucose tolerance alone is as strong a predictor of stroke as is the MetS defined by the World Health Organization, NCEP and updated NCEP criteria.
Jianjun Wang; Sanna Ruotsalainen; Leena Moilanen; Päivi Lepistö; Markku Laakso; Johanna Kuusisto
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-06
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  39     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-25     Completed Date:  2008-04-23     Revised Date:  2008-11-12    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1078-83     Citation Subset:  IM    
Department of Medicine, Cardiology Unit, Kuopio University Hospital, P.O. Box 1777, 70211 Kuopio, Finland.
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MeSH Terms
Blood Glucose
Cholesterol, HDL / blood
Finland / epidemiology
Follow-Up Studies
Metabolic Syndrome X / epidemiology*
Predictive Value of Tests
Proportional Hazards Models
Prospective Studies
Risk Factors
Sex Distribution
Stroke / epidemiology*
Reg. No./Substance:
0/Blood Glucose; 0/Cholesterol, HDL
Comment In:
Stroke. 2008 Nov;39(11):e163; author reply e164   [PMID:  18802205 ]
Stroke. 2008 Apr;39(4):1068-9   [PMID:  18323482 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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