| The metabolic syndrome of omega3-depleted rats. V. Intestinal phospholipid omega6 fatty acids. | |
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MedLine Citation:
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PMID: 19885631 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study aims mainly at investigating the effects of a dietary deprivation and replenishment of omega3 PUFA upon the phospholipid pattern of omega6 PUFA in the duodenum, jejunum, caecum and colon of rats exposed for 3-7 months to an omega3-depleted diet and then eventually exposed for 2-4 weeks to an omega3-rich diet. In control rats, the relative weight content of all omega6 fatty acids differed in the proximal and distal intestinal segments. In the omega3-depleted rats the C18:2omega6, C20:2omega6 and C20:3omega6 content was decreased whilst that of C20:4omega6 and C22:4omega6 was increased. Significant correlations were found in the caecum or colon between the C18:2omega6 or C20:4omega6 content of intestinal phospholipids and their C22:6omega3 content, an increase in the latter content coinciding with an increase in C18:2omega6 and decrease of C20:4omega6. Such was also the case for C20:4omega6, but not C18:2omega6, in the duodenum and jejunum. At these proximal intestinal levels, exposure of the omega3-depleted rats to a flaxseed oil-enriched diet indeed decreased the C18:2omega6 phospholipid content, an effect possibly attributable to the much lower content of C18:2omega6 in the latter diet, as distinct from the sunflower diet offered to the omega3-depleted rats during the first 7 months. However, at more distal intestinal levels, and like in the liver, a deficiency in omega3 fatty acids apparently favours the stepwise conversion of C18:2omega6 to C20:4omega6 and C22:4omega6. |
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Authors:
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Mirjam Hacquebard; Laurence Portois; Willy J Malaisse; Yvon A Carpentier |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of molecular medicine Volume: 24 ISSN: 1791-244X ISO Abbreviation: Int. J. Mol. Med. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-03 Completed Date: 2010-02-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9810955 Medline TA: Int J Mol Med Country: Greece |
Other Details:
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Languages: eng Pagination: 867-75 Citation Subset: IM |
Affiliation:
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Laboratory of Experimental Surgery, Universit?? Libre de Bruxelles, B-1070 Brussels, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fatty Acids, Omega-3 / metabolism* Fatty Acids, Omega-6 / metabolism* Female Intestines / chemistry, metabolism* Linear Models Linseed Oil / metabolism Metabolic Syndrome X / metabolism* Phospholipids / metabolism Rats |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Phospholipids; 8001-26-1/Linseed Oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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