Document Detail


The metabolic syndrome of omega3-depleted rats. I. Liver data.
MedLine Citation:
PMID:  19513543     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Second-generation rats depleted in long-chain polyunsaturated omega3 fatty acids were recently proposed as a novel animal model for the metabolic syndrome. In the present study, a dietary deprivation of omega3 acids for 3-7 months was found sufficient to provoke in 6-week-old normal rats the same alteration of the fatty acid content and profile of liver phospholipids and triglycerides as that otherwise prevailing in the second-generation omega3-depleted rats, with emphasis on a severe decrease in their omega3 fatty acid content, alterations in the relative contribution of and ratio between selected long-chain polyunsaturated omega6 fatty acids, saturated and monodesaturated fatty acids and precursors of nervonic acid, and liver steatosis. When the omega3-depleted rats were exposed, after the first 7 months of the present experiments and for 2-4 weeks to a diet supplemented with 5% (w/w) flaxseed oil, most of these hepatic variables returned towards or beyond control values. In both the omega3-depleted rats and control animals, however, the eventual exposure to the flaxseed oil-enriched diet failed to suppress liver steatosis and, on the contrary, provoked a further increase in liver triglyceride content. It is proposed, therefore, that the present approach represents a simple and realistic animal model to study the consequences of omega3-depletion. Moreover, the results suggest that to oppose such consequences, e.g. liver steatosis, it may be necessary to combine the dietary supply of omega3 acids with a suitable control of food intake, in both qualitative and quantitative terms.
Authors:
Willy J Malaisse; Nurdan Bulur; Ying Zhang; Mirjam Hacquebard; Laurence Portois; Abdullah Sener; Yvon A Carpentier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of molecular medicine     Volume:  24     ISSN:  1107-3756     ISO Abbreviation:  Int. J. Mol. Med.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-10     Completed Date:  2009-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9810955     Medline TA:  Int J Mol Med     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  111-23     Citation Subset:  IM    
Affiliation:
Laboratory of Experimental Hormonology, Université Libre de Bruxelles, B-1070 Brussels, Belgium. malaisse@ulb.ac.be
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MeSH Terms
Descriptor/Qualifier:
Animals
Fatty Acids, Omega-3 / administration & dosage,  metabolism*
Female
Liver / metabolism*
Metabolic Syndrome X / metabolism*
Phospholipids / metabolism
Rats
Triglycerides / metabolism
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Phospholipids; 0/Triglycerides

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