Document Detail


The metabolic syndrome entanglement: cutting the Gordian knot.
MedLine Citation:
PMID:  23677720     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Questions have been raised concerning the clinical value of the metabolic syndrome (MS). The negative opinion regarding MS is basically anchored on a separate analysis of four conditions: obesity, dyslipidemia, hypertension and glucose intolerance. The common denominator of these four sets of arguments is that they represent an utterly simplistic view of MS as a solely predictive tool of morbidity or mortality. We believe that it is inequitable to compare it with statistically constructed predictive tools, including stronger prognostic variables even unrelated to each other from the biological point of view. Several recent large meta-analyses - one of them including near one million patients - had systematically shown that people with MS are at increased risk of cardiovascular events. MS was associated with a 2-fold increase in cardiovascular outcomes and a 1.5-fold increase in all-cause mortality rates. A very important finding was that cardiovascular risk remained still high in patients with MS but without diabetes. The presence of MS possesses a definite predictive value, but first of all it is a widely accepted concept regarding a biological condition based on the complex and interrelated pathophysiological mechanisms emanating from excess central adiposity and insulin resistance. The risk factors are multiplicative, meaning that the risk for cardiovascular disease from risk factors rises geometrically, not linearly, as the number of risk factors increases. Therefore, currently available evidences strongly support the concept of the MS as a critical clustering of cardiovascular risk factors and diabetes, representing a true and solid evolving clinical entity.
Authors:
Enrique Z Fisman; Alexander Tenembaum
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-15
Journal Detail:
Title:  Cardiology journal     Volume:  -     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Cardiovascular Diabetology Research Foundation Holon, Israel. zfisman@post.tau.ac.il.
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