Document Detail


The metabolic syndrome and cardiovascular risk in Cushing's syndrome.
MedLine Citation:
PMID:  15850845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cushing's syndrome (CS) is characterized by a series of systemic complications that increase cardiovascular risk and cause severe atherosclerotic damage that develops in parallel with an acquired metabolic syndrome. Short-term remission from hypercortisolism improves metabolic and vascular damages, but long-term remission from CS seems to be associated with similar or worse metabolic and vascular damage, probably because of persistent abdominal obesity or insulin resistance years after normalization of cortisol secretion. Study results suggest that an increased cardiovascular risk also may persist in patients who undergo treatment with exogenous glucocorticoids after therapy withdrawal. Considering the many patients subjected to corticosteroid treatment, this could be of great clinical relevance and should be investigated thoroughly.
Authors:
Rosario Pivonello; Antongiulio Faggiano; Gaetano Lombardi; Annamaria Colao
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Endocrinology and metabolism clinics of North America     Volume:  34     ISSN:  0889-8529     ISO Abbreviation:  Endocrinol. Metab. Clin. North Am.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-04-26     Completed Date:  2005-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800104     Medline TA:  Endocrinol Metab Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-39, viii     Citation Subset:  IM    
Affiliation:
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via Sergio Pansini 5, Naples 80131, Italy. rpivone@tin.it
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MeSH Terms
Descriptor/Qualifier:
Cardiovascular Diseases / epidemiology*,  physiopathology
Humans
Metabolic Syndrome X / epidemiology*,  physiopathology
Pituitary ACTH Hypersecretion / epidemiology*,  physiopathology
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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