| The metabolic syndrome and cardiovascular risk in Cushing's syndrome. | |
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MedLine Citation:
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PMID: 15850845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cushing's syndrome (CS) is characterized by a series of systemic complications that increase cardiovascular risk and cause severe atherosclerotic damage that develops in parallel with an acquired metabolic syndrome. Short-term remission from hypercortisolism improves metabolic and vascular damages, but long-term remission from CS seems to be associated with similar or worse metabolic and vascular damage, probably because of persistent abdominal obesity or insulin resistance years after normalization of cortisol secretion. Study results suggest that an increased cardiovascular risk also may persist in patients who undergo treatment with exogenous glucocorticoids after therapy withdrawal. Considering the many patients subjected to corticosteroid treatment, this could be of great clinical relevance and should be investigated thoroughly. |
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Authors:
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Rosario Pivonello; Antongiulio Faggiano; Gaetano Lombardi; Annamaria Colao |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Endocrinology and metabolism clinics of North America Volume: 34 ISSN: 0889-8529 ISO Abbreviation: Endocrinol. Metab. Clin. North Am. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-04-26 Completed Date: 2005-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800104 Medline TA: Endocrinol Metab Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 327-39, viii Citation Subset: IM |
Affiliation:
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Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via Sergio Pansini 5, Naples 80131, Italy. rpivone@tin.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiovascular Diseases
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epidemiology*,
physiopathology Humans Metabolic Syndrome X / epidemiology*, physiopathology Pituitary ACTH Hypersecretion / epidemiology*, physiopathology Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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